Infigratinib (NVP-BGJ398, BGJ398) | FGFR inhibitor | Probechem Biochemicals

Chemical Structure : Infigratinib

CAS No.: 872511-34-7

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Infigratinib (NVP-BGJ398, BGJ-398, BGJ398)

货号: PC-43484Not For Human Use, Lab Use Only.

Infigratinib (NVP-BGJ398, BGJ398) is a potent, selective pan-FGFR inhibitor with IC50 of 0.9/1.0/1.4/60 nM for FGFR1/2/3/4, also shows high potenct against mutant FGFR3-K650E with IC50 of 4.9 nM.

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25 mg	￥880	In stock
50 mg	￥1280	In stock
100 mg	￥2180	In stock
250 mg	￥3780	In stock
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生物&药学活性

Infigratinib (NVP-BGJ398, BGJ398) is a potent, selective pan-FGFR inhibitor with IC50 of 0.9/1.0/1.4/60 nM for FGFR1/2/3/4, also shows high potenct against mutant FGFR3-K650E with IC50 of 4.9 nM.
Infigratinib (NVP-BGJ398, BGJ398) inhibits the proliferation of the FGFR1-, FGFR2-, and FGFR3-dependent BaF3 cells with IC50 of low nanomolar range.
Infigratinib (NVP-BGJ398, BGJ398) shows significant antitumor activity in RT112 bladder cancer xenografts models overexpressing wild-type FGFR3.
Infigratinib (NVP-BGJ398, BGJ398) significantly inhibits the growth of FGFR2-mutated endometrial cancer xenograft models, also ameliorates FGF23-mediated hypophosphatemic rickets in mouse models.

物理化学性质&存储条件

分子量	560.48
分子式	C26H31Cl2N7O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: 27 mg/mL
Chemical Name/SMILES	Urea, N'-(2,6-dichloro-3,5-dimethoxyphenyl)-N-[6-[[4-(4-ethyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]-N-methyl-

参考文献

1. Guagnano V, et al. J Med Chem. 2011 Oct 27;54(20):7066-83.

2. Guagnano V, et al. Cancer Discov. 2012 Dec;2(12):1118-33.

3. Konecny GE, et al. Mol Cancer Ther. 2013 May;12(5):632-42.

Infigratinib (NVP-BGJ398, BGJ-398, BGJ398)

生物&药学活性

物理化学性质&存储条件

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Infigratinib (NVP-BGJ398, BGJ-398, BGJ398)

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物理化学性质&存储条件

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