Indisulam (E7070) | Carbonic Anhydrase inhibitor | Probechem Biochemicals

Chemical Structure : Indisulam

CAS No.: 165668-41-7

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Indisulam (E 7070, E7070)

货号: PC-62314Not For Human Use, Lab Use Only.

Indisulam (E7070) is potent, sulfonamide, carbonic anhydrase inhibitor that possesses antiproliferative activities, causes decrease in the S phase fraction along with G1 and/or G2 accumulation in various cancer cell lines.

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10 mg	￥880	In stock
25 mg	￥1480	In stock
50 mg	￥2280	In stock
100 mg		Get quote

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生物&药学活性

Indisulam (E7070) is potent, sulfonamide, carbonic anhydrase inhibitor that possesses antiproliferative activities, causes decrease in the S phase fraction along with G1 and/or G2 accumulation in various cancer cell lines.
Indisulam (E7070) targets splicing by inducing RBM39 degradation via recruitment to DCAF15
Indisulam causes blockade in the G1/S transition through inhibition of the activation of both CDK2 and cyclin E, shows activity in multiple tumor types, most prominently in colon and lung cancer.

物理化学性质&存储条件

分子量	385.85
分子式	C14H12ClN3O4S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3-chloro-7-indolyl)-1,4-benzenedisulfonamide

参考文献

1. van Kesteren C, et al. Br J Clin Pharmacol. 2002 Nov;54(5):463-71.

2. Owa T, et al. J Med Chem. 2002 Oct 24;45(22):4913-22.

3. Ozawa Y, et al. Eur J Cancer. 2001 Nov;37(17):2275-82.

4. Tsukahara K, et al. Mol Pharmacol. 2001 Dec;60(6):1254-9.

Indisulam (E 7070, E7070)

生物&药学活性

物理化学性质&存储条件

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Indisulam (E 7070, E7070)

生物&药学活性

物理化学性质&存储条件

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