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首页-小分子抑制剂&激动剂-Others-PCSK9-Inclisiran
Inclisiran

Chemical Structure : Inclisiran

CAS No.: 1639324-58-5

Inclisiran

货号: PC-25140Not For Human Use, Lab Use Only.

Inclisiran is a double-stranded small interfering RNA (siRNA) molecule that inhibit the transcription of PCSK9, inhibits Pyroptosis, activates PPARγ, and reduces NLRP3, cleaved caspase-1, IL-1β, and IL-18, shows anti-inflammatory, lipid-regulating and anti-atherosclerotic activities.

规格 价格 库存 数量
1 mg ¥2580 In stock
2 mg ¥3980 In stock
5 mg ¥5980 In stock
10 mg Get quote
25 mg Get quote

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Inclisiran is a double-stranded small interfering RNA (siRNA) molecule that inhibit the transcription of PCSK9, inhibits Pyroptosis, activates PPARγ, and reduces NLRP3, cleaved caspase-1, IL-1β, and IL-18, shows anti-inflammatory, lipid-regulating and anti-atherosclerotic activities.

物理化学性质&存储条件

分子量 16339 (1 mg= 61nmol, 5 mg= 306nmol)
分子式
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

RNA, (Am-sp-(2'-deoxy-2'-fluoro)C-sp-Am-(2'-deoxy-2'-fluoro)A-(2'-deoxy-2'- fluoro)A-(2'-deoxy-2'-fluoro)A-Gm-(2'-deoxy-2'-fluoro)C-Am-(2'-deoxy-2'-fluoro)AAm-(2'-deoxy-2'-fluoro)A-Cm-(2'-deoxy-2'-fluoro)A-Gm-(2'-deoxy-2'-fluoro)G-Um-(2'-deoxy-2'-fluoro)C-Um-Am-Gm-sp-Am-sp-Am), complex with RNA (Cm-sp-Umsp -Am-Gm-Am-Cm-(2'-deoxy-2'-fluoro)C-Um-(2'-deoxy-2'-fluoro)G-Um-dT-UmUm-Gm-Cm-Um-Um-Um-Um-Gm-Um) 3'-[[(2S,4R)-1-[29-[[2-(acetylamino)-2- deoxy-β-D-galactopyranosyl]oxy]-14,14-bis[[3-[[3-[[5-[[2

参考文献

1. Constantine E Kosmas, et al. Ther Clin Risk Manag. 2020 Oct 28;16:1031-1037.

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