Chemical Structure : Inclisiran
CAS No.: 1639324-58-5
货号: PC-25140Not For Human Use, Lab Use Only.
Inclisiran is a double-stranded small interfering RNA (siRNA) molecule that inhibit the transcription of PCSK9, inhibits Pyroptosis, activates PPARγ, and reduces NLRP3, cleaved caspase-1, IL-1β, and IL-18, shows anti-inflammatory, lipid-regulating and anti-atherosclerotic activities.
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥2580 | In stock | |
2 mg | ¥3980 | In stock | |
5 mg | ¥5980 | In stock | |
10 mg | Get quote | ||
25 mg | Get quote |
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Inclisiran is a double-stranded small interfering RNA (siRNA) molecule that inhibit the transcription of PCSK9, inhibits Pyroptosis, activates PPARγ, and reduces NLRP3, cleaved caspase-1, IL-1β, and IL-18, shows anti-inflammatory, lipid-regulating and anti-atherosclerotic activities.
分子量 | 16339 (1 mg= 61nmol, 5 mg= 306nmol) | |
分子式 | ||
外观性状 | Solid | |
储存条件 |
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Solubility |
10 mM in DMSO |
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Chemical Name/SMILES |
RNA, (Am-sp-(2'-deoxy-2'-fluoro)C-sp-Am-(2'-deoxy-2'-fluoro)A-(2'-deoxy-2'- fluoro)A-(2'-deoxy-2'-fluoro)A-Gm-(2'-deoxy-2'-fluoro)C-Am-(2'-deoxy-2'-fluoro)AAm-(2'-deoxy-2'-fluoro)A-Cm-(2'-deoxy-2'-fluoro)A-Gm-(2'-deoxy-2'-fluoro)G-Um-(2'-deoxy-2'-fluoro)C-Um-Am-Gm-sp-Am-sp-Am), complex with RNA (Cm-sp-Umsp -Am-Gm-Am-Cm-(2'-deoxy-2'-fluoro)C-Um-(2'-deoxy-2'-fluoro)G-Um-dT-UmUm-Gm-Cm-Um-Um-Um-Um-Gm-Um) 3'-[[(2S,4R)-1-[29-[[2-(acetylamino)-2- deoxy-β-D-galactopyranosyl]oxy]-14,14-bis[[3-[[3-[[5-[[2 |
1. Constantine E Kosmas, et al. Ther Clin Risk Manag. 2020 Oct 28;16:1031-1037.
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