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首页-小分子抑制剂&激动剂-Others-Other Targets-Imifoplatin
Imifoplatin

Chemical Structure : Imifoplatin

CAS No.: 1339960-28-9

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Imifoplatin (PT-112)

货号: PC-25340Not For Human Use, Lab Use Only.

Imifoplatin (PT-112) is the first pyrophosphate-platinum conjugate, causes immunogenic cell death in experimental models, is an immunogenic cell death (ICD)-inducing small molecule, inhibits ribosome biogenesis and causes organelle stresses, leading to selective ICD in cancer cells.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

Imifoplatin (PT-112) is the first pyrophosphate-platinum conjugate, causes immunogenic cell death in experimental models, is an immunogenic cell death (ICD)-inducing small molecule, inhibits ribosome biogenesis and causes organelle stresses, leading to selective ICD in cancer cells.

物理化学性质&存储条件

分子量 485.23
分子式 C6H16N2O7P2Pt
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

参考文献

1. Yamazaki T, et al. Oncoimmunology. 2020 Feb 11;9(1):1721810.

2. Karp DD, et al. EClinicalMedicine. 2022 May 27;49:101430.

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