Ifetroban sodium (BMS-180291, CPI211)

Chemical Structure : Ifetroban sodium

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货号: PC-20715Not For Human Use, Lab Use Only.

Ifetroban sodium (BMS-180291, CPI211) is a potent and highly selective antagonist of thromboxane A2/prostaglandin endoperoxide (TP) receptors, inhibits platelet aggregation induced by arachidonate (800 uM) and U-46,619 (10 uM) with IC50 of 7 and 21 nM, respectively.

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生物&药学活性

Ifetroban sodium (BMS-180291, CPI211) is a potent and highly selective antagonist of thromboxane A2/prostaglandin endoperoxide (TP) receptors, inhibits platelet aggregation induced by arachidonate (800 uM) and U-46,619 (10 uM) with IC50 of 7 and 21 nM, respectively.
BMS 180,291 antagonized U-46,619-induced platelet shape change competitively with a KB of 11 nM.
BMS 180,291 did not inhibit platelet aggregation induced by high concentrations of ADP (20 microM) or human alpha-thrombin (1 U/ml) at 1 uM. BMS 180,291 antagonized U-46,619-induced concentrations of rat aortae with a KB of 0.6 nM.
Ifetroban sodium (BMS-180291, CPI211) potently blocked spontaneous metastasis from primary tumors, without affecting tumor cell proliferation, motility, or tumor growth.

物理化学性质&存储条件

分子量	462.52
分子式	C25H31N2NaO5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	sodium 3-(2-(((1S,2R,3S,4R)-3-(4-(pentylcarbamoyl)oxazol-2-yl)-7-oxabicyclo[2.2.1]heptan-2-yl)methyl)phenyl)propanoate

参考文献

1. M L Ogletree, et al. J Pharmacol Exp Ther. 1993 Feb;264(2):570-8.

2. Werfel TA, et al. Mol Cancer Ther. 2020 Dec;19(12):2454-2464.