Icotinib hydrochloride | EGFR inhibitor | Probechem Biochemicals

Chemical Structure : Icotinib hydrochloride

CAS No.: 1204313-51-8

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Icotinib hydrochloride (BPI-2009H)

货号: PC-22088Not For Human Use, Lab Use Only.

Icotinib hydrochloride (BPI-2009H) is a potent and specific EGFR inhibitor with IC50 of 5 nM, also inhibits mutant EGFRL858R, EGFR L858R/T790M, EGFR T790M and EGFR L861Q.

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10 mg	￥1780	In stock
25 mg	￥2980	In stock
50 mg	￥4580	In stock
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生物&药学活性

Icotinib hydrochloride (BPI-2009H) is a potent and specific EGFR inhibitor with IC50 of 5 nM, also inhibits mutant EGFRL858R, EGFR L858R/T790M, EGFR T790M and EGFR L861Q.
Icotinib only shows meaningful inhibitory activity to EGFR and its mutants against a panel of 88 kinases.
Icotinib blocks EGFR-mediated intracellular tyrosine phosphorylation (IC(50)=45 nM) in the human epidermoid carcinoma A431 cell line and inhibits tumor cell proliferation.
Icotinib exhibits potent dose-dependent antitumor effects in nude mice carrying a variety of human tumor-derived xenografts.

物理化学性质&存储条件

分子量	427.89
分子式	C22H22ClN3O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3-Ethynylphenyl)-7,8,10,11,13,14-hexahydro-[1,4,7,10]tetraoxacyclododecino[2,3-g]quinazolin-4-amine hydrochloride

参考文献

1. Tan F, et al. Lung Cancer. 2012 May;76(2):177-82.

2. Yang G, et al. Oncol Rep. 2012 Jun;27(6):2066-72.

Icotinib hydrochloride (BPI-2009H)

生物&药学活性

物理化学性质&存储条件

参考文献

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Icotinib hydrochloride (BPI-2009H)

生物&药学活性

物理化学性质&存储条件

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