欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-IRE1-IXA4
IXA4

Chemical Structure : IXA4

CAS No.: 1185329-96-7

加入收藏

IXA4 (IRE1 activator)

货号: PC-23415Not For Human Use, Lab Use Only.

IXA4 is a specific activator of IRE1/XBP1s signalling activator, promotes IRE1-dependent XBP1 splicing, selective activates the IRE1/XBP1s signaling, also binds to SLC33A1 and inhibits its activity.

规格 价格 库存 数量
10 mg ￥880 In stock
25 mg ￥1380 In stock
50 mg ￥2280 In stock
100 mg Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

IXA4 is a specific activator of IRE1/XBP1s signalling activator, promotes IRE1-dependent XBP1 splicing, selective activates the IRE1/XBP1s signaling, also binds to SLC33A1 and inhibits its activity.
IXA4 does not affect the UPR or other stress-responsive signaling pathways.
IXA4 increases IRE1 RNase activity through a mechanism independent of binding the IRE1 nucleotide-binding pocket.
IXA4 is distinct from currently available IRE1 activators, which bind the kinase active site.
IXA4 improves ER proteostasis of AD-relevant APP mutants, reducing the secretion of Aβ through the increased targeting of APP to degradation.
IXA4 reduces mitochondrial dysfunction associated with mutant APP overexpression, likely reflecting the reduced intracellular APP afforded by compound treatment.
IXA4 selectively reduces viability of KEAP1-deficient lung adenocarcinoma cells that have elevated levels of glutathione, mimicking the sensitivity of these cells to genetic deletion of SLC33A1.

物理化学性质&存储条件

分子量 436.51
分子式 C24H28N4O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1H-Pyrazole-1-acetamide, N-methyl-N-[2-(4-methylphenoxy)ethyl]-4-[(1-oxo-3-phenoxypropyl)amino]-

参考文献

1. Grandjean JMD, et al. Nat Chem Biol. 2020 Oct;16(10):1052-1061.

备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

联系我们 sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

询单

  • *产品名称:
  • *姓名:
  • *邮箱:
  • *公司名称:
  • *询单数量:
  • *国籍:
  • 询单信息: