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首页-小分子抑制剂&激动剂-Wnt/Notch/Hedgehog-Wnt-IWP-3
IWP-3

Chemical Structure : IWP-3

CAS No.: 687561-60-0

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IWP-3

货号: PC-25594Not For Human Use, Lab Use Only.

IWP-3 is a potent, small molecule inhibitor of Wnt production with IC50 of 40 nM, inhibits Porcupine (Porcn) function thereby blocking palmitoylation of Wnt proteins, inhibits CK1γ3 and CK1ε, does not inhibit CK1α.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

IWP-3 is a potent, small molecule inhibitor of Wnt production with IC50 of 40 nM, inhibits Porcupine (Porcn) function thereby blocking palmitoylation of Wnt proteins, inhibits CK1γ3 and CK1ε, does not inhibit CK1α.

物理化学性质&存储条件

分子量 484.58
分子式 C22H17FN4O2S3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-((3-(4-Fluorophenyl)-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(6-methylbenzo[d]thiazol-2-yl)acetamide

参考文献

1. Baozhi Chen, et al. Nat Chem Biol. 2009 Feb;5(2):100-7.

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