IU1-47 |CAS:670270-31-2 Probechem Biochemicals

Chemical Structure : IU1-47

CAS No.: 670270-31-2

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IU1-47 (USP14 inhibitor IU1-47)

货号: PC-62623Not For Human Use, Lab Use Only.

IU1-47 is a potent, selective small-molecule inhibitor of USP14 with IC50 of 0.6 uM, shows 10-fold more potent over IU1 and retains specificity for USP14.

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10 mg	￥1880	In stock
25 mg	￥2980	In stock
100 mg	￥6980	In stock
250 mg		Get quote
1 g		Get quote

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生物&药学活性

IU1-47 is a potent, selective small-molecule inhibitor of USP14 with IC50 of 0.6 uM, shows 10-fold more potent over IU1 and retains specificity for USP14.
IU1-47 accelerates the rate of degradation of wild-type tau, the pathological tau mutants P301L and P301S, and the A152T tau variant in primary neuronal cultures, a specific residue in tau, lysine 174, is critical for the IU1-47-mediated tau degradation by the proteasome.
IU1-47 stimulates autophagic flux in primary neurons.

物理化学性质&存储条件

分子量	330.856
分子式	C19H23ClN2O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(1-(4-Chlorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl)-2-(piperidin-1yl)ethanone

参考文献

1. Boselli M, et al. J Biol Chem. 2017 Nov 24;292(47):19209-19225.

IU1-47 (USP14 inhibitor IU1-47)

生物&药学活性

物理化学性质&存储条件

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IU1-47 (USP14 inhibitor IU1-47)

生物&药学活性

物理化学性质&存储条件

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