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首页-新冠病毒相关-SARS-CoV-2 Inhibitors-ISM3312
ISM3312

Chemical Structure : ISM3312

CAS No.: 2925114-53-8

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ISM3312 (ISM-3312)

货号: PC-24641Not For Human Use, Lab Use Only.

ISM3312 is a potent, irreversible covalent broad-spectrum inhibitor of human coronavirus main protease (Mpro) with IC50 of 14 nM, exhibits potent cellular potency in VeroE6 cell lines with EC50 of 71 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

ISM3312 is a potent, irreversible covalent broad-spectrum inhibitor of human coronavirus main protease (Mpro) with IC50 of 14 nM, exhibits potent cellular potency in VeroE6 cell lines with EC50 of 71 nM.
ISM3312 effectively binds to a variety of CoV catalytic pockets without collision.
ISM3312 exhibited a broad and potent inhibition against Mpro derived from a panel of coronaviruses (Omicron P132H, SARS-CoV, HCoV-229E, HCoV-OC43, HCoV-NL63, HCoV-HKU1 and MERS-CoV) with IC50 of 4-52 nM.
ISM3312 exhibited potent antiviral efficacy against a spectrum of tested SARS-CoV-2 variants including the ancestral, Delta, BA.2.3, BA.5, XBB.1, and EG.5 with EC50 of 0.03-0.14 uM in VeroE6 CPE-based assays.
ISM3312 exhibited lower EC50s against the low pathogenicity coronavirus strains 229E, NL63, and OC43 than Nirmatrelvir and Ensitrelvir with EC50 values of 19, 167, and 56  nM, respectively.
ISM3312 exhibits potent antiviral activity against various coronaviruses in human proximal airway organoid model
ISM3312 inhibits a spectrum of CoVs in vivo, shows significant inhibitory effects against Nirmatrelvir-resistant Mpro mutants.

物理化学性质&存储条件

分子量 521.32
分子式 C21H21Cl2F3N4O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(R)-2-((R)-2-chloro-N-(4-(chlorodifluoromethoxy)phenyl)-2-fluoroacetamido)-2-(pyrimidin-5-yl)-N-(tetrahydro-2H-pyran-4-yl)propanamide

参考文献

1. Jing Sun, et al. Nat Commun. 2025 May 15;16(1):4546.

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