IRBM-Z-2

Chemical Structure : IRBM-Z-2

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货号: PC-26057Not For Human Use, Lab Use Only.

规格	价格	库存	数量
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250 mg		Get quote

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生物&药学活性

IRBM-Z-2 is a potent, non-competitive, allosteric inhibitor of ZIKV NS3 protease with binding KD of 21 nM (ZIKV NS2B-NS3 protease) and biochemical IC50 of 42 nM, potently inhibits both ZIKV viral replication (IC50=25 nM) and infectivity of ZIKV (CPE IC50=16 nM).
IRBM-Z-2 exhibits antiviral activity against additional ZIKV strains, including Padova and H/PF/2013, in human HuH-7 cells with apparent IC50 values ranging from 6 to 20 nM.
IRBM-Z-2 displays inhibitory activity against other orthoflavivirus proteases, such as DENV2 and WNV, with potencies ranging from nanomolar to low micromolar in both biochemical and cell-based assays.
IRBM-Z-2 (100 mg/kg, i.p.) caused rapid and marked antiviral activity in mouse models of ZIKV infection.

物理化学性质&存储条件

分子量	469.43
分子式	C22H18F3N7O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Urea, N-[3-[[5-(4,6-dimethyl-5-pyrimidinyl)-2-pyridinyl]methyl]-1,2,3-oxadiazolium-5-yl]-N′-[3-(trifluoromethyl)phenyl]-, inner salt

参考文献

1. Ontoria JM, et al. Nat Commun. 2026 Feb 10;17(1):1439.

IRBM-Z-2

生物&药学活性

物理化学性质&存储条件

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IRBM-Z-2

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物理化学性质&存储条件

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