IR-546 | NIR fluorescent | Probechem Biochemicals

Chemical Structure : IR-546

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IR-546 (IR546)

货号: PC-24905Not For Human Use, Lab Use Only.

IR-546 is a NIR fluorescent probe, inhibits melanoma cell proliferation by activating the mitochondrial apoptosis pathway through suppression of the AKT/GSK3β signaling pathway.

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生物&药学活性

IR-546 is a NIR fluorescent probe, inhibits melanoma cell proliferation by activating the mitochondrial apoptosis pathway through suppression of the AKT/GSK3β signaling pathway.
IR-546 exhibits an absorption peak at 600 nm, and an emission peak at 605 nm and 650 nm, confirming its near-infrared (NIR) fluorescence properties (600–900 nm).
IR-546 exhibits cell-killing effect on melanoma cellsin vitro and in vivo.
IR-546 shows MTT IC50 of 2.4, 0.7, and 0.2 µM for A375 melanoma cells at 24 h, 48 h, and 72 h, respectively, and for B16-F10 melanoma cells is 4.3, 1.7, and 1.0 µM, respectively.
IR-546 induces apoptosis of melanoma cells by affecting mitochondrial function.
IR-546 inhibits the metastasis of A375 and B16-F10 melanoma cells.
IR-546 inhibits the growth of melanoma without obvious side effects in vivo.

物理化学性质&存储条件

分子量	748.72
分子式	C41H37IN2O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-2-(2-(5-(4-(bis(4-methoxyphenyl)amino)phenyl)thiophen-2-yl)vinyl)-1,1,3-trimethyl-1H-benzo[e]indol-3-ium iodide

参考文献

1. Hongye Liao, et al. Mol Med. 2025 Jun 10;31(1):226.

IR-546 (IR546)

生物&药学活性

物理化学性质&存储条件

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IR-546 (IR546)

生物&药学活性

物理化学性质&存储条件

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