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首页-小分子抑制剂&激动剂-Others-Other Targets-IPR-803
IPR-803

Chemical Structure : IPR-803

CAS No.: 892243-35-5

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IPR-803 (IPR803)

货号: PC-25259Not For Human Use, Lab Use Only.

IPR-803 is a small molecule inhibitor of the uPAR·uPA protein-protein interaction, binds directly to uPAR with sub-micromolar affinity of 0.2 uM.

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5 mg ￥1880 In stock
10 mg ￥2980 In stock
25 mg ￥4980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

IPR-803 is a small molecule inhibitor of the uPAR·uPA protein-protein interaction, binds directly to uPAR with sub-micromolar affinity of 0.2 uM.
IPR-803 blocks invasion of breast MDA-MB-231, and inhibits matrix metalloproteinase (MMP) breakdown of the extracellular matrix (ECM).
IPR-803 also inhibits MMP activity and blocked invasion in a concentration-dependent manner.
IPR-803 impairs MDA-MB-231 cell adhesion and migration.

物理化学性质&存储条件

分子量 453.50
分子式 C27H23N3O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-((3-(Azepan-1-yl)-6-oxo-6H-anthra[1,9-cd]isoxazol-5-yl)amino)benzoic acid

参考文献

1. Khanna M, et al. ACS Chem Biol. 2011 Nov 18;6(11):1232-43.

2. Mani T, et al. Bioorg Med Chem. 2013 Apr 1;21(7):2145-55.

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