IP6C

Chemical Structure : IP6C

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货号: PC-24460Not For Human Use, Lab Use Only.

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生物&药学活性

IP6C is a small molecule inhibitor of type II Thoeris systems encoded by multiple bacteria species, inhibits BaY2 Thoeris with IC50 of 10 uM, inhibits the type II Thoeris system by blocking His-ADPR production by ThsB.
IP6C blocks production of the His-ADPR alarm signal.
IP6C also promotes the reproduction of SPO1 on B. subtilis cells expressing BaY2 Thoeris.
IP6C indirectly inhibit ThsA activation by competitively inhibiting His-ADPR production by ThsB.
IP6C inhibits type II Thoeris systems of antibiotic-resistant pathogens.
IP6C improves the survival rate of mice undergoing phage therapy against phage-resistant P. aeruginosa containing the type II Thoeris system.

物理化学性质&存储条件

分子量	161.16
分子式	C8H7N3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	imidazo[1,2-a]pyridine-6-carboxamide

参考文献

1. Zang Z, et al. bioRxiv [Preprint]. 2025 Feb 21:2025.02.20.638879.

IP6C

生物&药学活性

物理化学性质&存储条件

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IP6C

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物理化学性质&存储条件

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