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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Bacterial-INP-0400
INP-0400

Chemical Structure : INP-0400

CAS No.: 1403765-57-0

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INP-0400 (INP 0400, INP0400)

货号: PC-70255Not For Human Use, Lab Use Only.

INP-0400 (INP0400) is a small-molecule inhibitor of type III secretion (TTS, T3SS) in Chlamydia trachomatis, inhibits intracellular replication and infectivity of C. trachomatis at micromolar concentrations, inhibits C. trachomatis reticulate bodies (RB) multiplication, binds effectively with YspD.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    INP-0400 (INP0400) is a small-molecule inhibitor of type III secretion (TTS, T3SS) in Chlamydia trachomatis, inhibits intracellular replication and infectivity of C. trachomatis at micromolar concentrations, inhibits C. trachomatis reticulate bodies (RB) multiplication, binds effectively with YspD.
    INP0400 inhibits reticulate bodies (RB) multiplication resulting in small inclusion bodies (SIB).
    INP0400 inhibits homotypic vesicle fusion of SIB.
    INP0400 inhibits terminal RB-to-elementary bodies (EB) differentiation during the late cycle.
    INP0400 partially inhibits uptake of EBs, suggesting an inhibitory effect on the internalization process.

    物理化学性质&存储条件

    分子量 324.764
    分子式 C18H13ClN2O2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (E)-4-chloro-N'-((2-hydroxynaphthalen-1-yl)methylene)benzohydrazide

    参考文献

    1. Muschiol S, et al. Proc Natl Acad Sci U S A. 2006 Sep 26;103(39):14566-71.

    2. Muschiol S, et al. BMC Microbiol. 2009 Apr 21;9:75.

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