INNO-220 | CK1α degrader | Probechem Biochemicals

Chemical Structure : INNO-220

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INNO-220 (INNO220)

货号: PC-24767Not For Human Use, Lab Use Only.

INNO-220 is a highly selective and potent, CRBN-dependent, orally bioavailable degrader of CK1α without affecting IKZF1/3, impairs cell viability and selectively degraded CK1α in lymphoma cells.

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100 mg		Get quote

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生物&药学活性

INNO-220 is a highly selective and potent, CRBN-dependent, orally bioavailable degrader of CK1α without affecting IKZF1/3, impairs cell viability and selectively degraded CK1α in lymphoma cells.
INNO-220 inhibits cells harboring wild-type p53 and exhibiting constitutive NF-κB signaling.
INNO-220 inhibits IL-2 expression by disrupting the CBM complex and inhibiting NF-κB activity.
INNO-220 suppresses NF-κB signaling and activates p53 pathway, leading to complete inhibition of lymphoma tumor growth in vivo.
INNO-220 disrupts the assembly and function of the CARD11/BCL10/MALT1 complex, thereby inhibiting NF-κB signaling in stimulated T cells and lymphoma cells that harbor an activating mutation in CARD11.

物理化学性质&存储条件

分子量	400.44
分子式	C23H20N4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(5-(1-Methyl-5-phenyl-1H-pyrazol-4-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione

参考文献

1. Feng S, et al. Leukemia. 2025 May 27. doi: 10.1038/s41375-025-02647-x.

2. Patent WO2024054832 A1.

INNO-220 (INNO220)

生物&药学活性

物理化学性质&存储条件

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INNO-220 (INNO220)

生物&药学活性

物理化学性质&存储条件

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