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首页-小分子抑制剂&激动剂-Immunology/Inflammation-STING-INI3069
INI3069

Chemical Structure : INI3069

CAS No.: 3124202-01-0

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INI3069 (INI-3069)

货号: PC-27088Not For Human Use, Lab Use Only.

INI3069 is a human-selective STING agonist, inhibits trafficking of STING to the Golgi and blocks STING-mediated TFEB dephosphorylation and autophagy, enhances both humoral responses to co-administered antigen and anti-tumor responses.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    INI3069 is a human-selective STING agonist, inhibits trafficking of STING to the Golgi and blocks STING-mediated TFEB dephosphorylation and autophagy, enhances both humoral responses to co-administered antigen and anti-tumor responses.
    INI3069 induce STING- and IRF3-dependent but ATG5-independent antiviral activity.
    INI3069 suppressed CHIKV in THF-MAVS/TRIF−/− (IC50=0.6758 μM) and THF-ATG5−/− cells (IC50 = 0.5171 μM).
    INI3069 elicits phosphorylation of TBK1 that was enhanced in STING+/+ and measurable in STING−/− cells.
    INI3069 does not bind to the STING cytosolic domain and requires an intact TMD oligomerization domain for activation.
    INI3069 blocks agonist-mediated Golgi trafficking and STING-mediated autophagy.
    INI3069 blocks STING-mediated TFEB dephosphorylation and autophagy.
    INI3069 enhances both humoral responses to co-administered antigen and anti-tumor responses.
    INI3069 induces different molecular and immune effects compared to conventional STING agonists.

    物理化学性质&存储条件

    分子量 476.45
    分子式 C23H16F4N2O3S
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4-(2-fluoro-6-hydroxybenzyl)-3-oxo-N-(2,4,6-trifluorobenzyl)-3,4-dihydro-2H-benzo[b][1,4]thiazine-6-carboxamide

    参考文献

    1. Mizuno N, et al. Cell Rep. 2026 Jun 1;45(6):117475.

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