INI-4001

Chemical Structure : INI-4001

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货号: PC-27719Not For Human Use, Lab Use Only.

INI-4001 is a selective, synthetic TLR7/8 agonist with EC50 of 1.89/4.86 uM, regulates innate and adaptive immune responses, acts as a vaccine adjuvant.

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生物&药学活性

INI-4001 is a selective, synthetic TLR7/8 agonist with EC50 of 1.89/4.86 uM, regulates innate and adaptive immune responses, acts as a vaccine adjuvant.
INI-4001 enhances IgG and neutralizing antibody responses against Powassan virus (POWV), reduces viral loads in the brain, liver and spleen, provides complete protection against lethal POWV challenge, and skews immune responses toward a Th1 phenotype.

物理化学性质&存储条件

分子量	1141.52
分子式	C59H109N6O13P
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S)-3-(2-(2-(2-(((2-(4-((6-amino-8-oxo-2-(((S)-pentan-2-yl)oxy)-7,8-dihydro-9H-purin-9-yl)methyl)piperidin-1-yl)ethoxy)(hydroxy)phosphoryl)oxy)ethoxy)ethoxy)ethoxy)propane-1,2-diyl dipalmitate

参考文献

1. Miller SM, et al. NPJ Vaccines. 2023 Jul 10;8(1):97.

INI-4001

生物&药学活性

物理化学性质&存储条件

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INI-4001

生物&药学活性

物理化学性质&存储条件

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