INCB191358 | DGKα/ζ inhibitor | Probechem Biochemicals

Chemical Structure : INCB191358

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INCB191358 (INCB-191358)

货号: PC-26580Not For Human Use, Lab Use Only.

INCB191358 is a potent, selective, and orally bioavailable dual DGKα/ζ inhibitor with IC50 of 0.12/0.36 nM respectively, shows good selectivity over Type I DGK isoforms.

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生物&药学活性

INCB191358 is a potent, selective, and orally bioavailable dual DGKα/ζ inhibitor with IC50 of 0.12/0.36 nM respectively, shows good selectivity over Type I DGK isoforms.
INCB191358 shows potent activity in the cellular (EC50 = 12 nM) assay and excellent activity in human whole blood (h-WB EC50 = 22 nM).
INCB191358 induced robust, dose-dependent CD8+ T-cell activation in the OT-I murine model and, in combination with anti-PD-1, produced significant antitumor activity in the MC38 syngeneic mouse model.

物理化学性质&存储条件

分子量	505.54
分子式	C25H30F3N5O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3,8-Dimethyl-6-((2S,4S)-2-methyl-4-(4-(trifluoromethyl)phenoxy)piperidin-1-yl)-9-(((S)-tetrahydrofuran-2-yl)methyl)-3,9-dihydro-2H-purin-2-one

参考文献

1. Wei B, et al. J Med Chem. 2026 Apr 17. doi: 10.1021/acs.jmedchem.5c03768.

INCB191358 (INCB-191358)

生物&药学活性

物理化学性质&存储条件

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INCB191358 (INCB-191358)

生物&药学活性

物理化学性质&存储条件

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