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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-ROR-IMU-935
IMU-935

Chemical Structure : IMU-935

CAS No.: 2299252-72-3

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IMU-935 (Izumerogant, IMU935, IM105935)

货号: PC-20040Not For Human Use, Lab Use Only.

IMU-935 (Izumerogant, IMU935, IM105935) is a potent, selective and orally available inverse agonist of retinoic acid-related orphan receptor gamma (RORγt) with IC50 of 24 nM.

规格 价格 库存 数量
5 mg ￥2580 In stock
10 mg ￥3980 In stock
25 mg ￥5980 In stock
50 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

IMU-935 (Izumerogant, IMU935, IM105935) is a potent, selective and orally available inverse agonist / inhibitor of retinoic acid-related orphan receptor gamma (RORγt) with IC50 of 24 nM.
IMU-935 is shown to be a DHODH Inhibitor with an IC50 of 240 nM.
IMU-935 demonstrates synergistic inhibition of the secretion of IL-17A, IL-17F and IFNγ with IC50 concentrations of 3-5 nM tested in stimulated human lymphocytes.
IMU-935 inhibits Th17 differentiation of murine cells (IC50=135 nM), and inhibits IL-17F production from stimulated human PBMCs with IC50 of 2-4 nM.
IMU-935 demonstrates a strong inhibition of GM-CSF, IL-17A, IL-17F and IL-22 in inflamed human skin model (skin punches from human healthy volunteers).
IMU-935 inhibits Th17 differentiation and reduced EAE severity without affecting thymocyte development by selectively targeting the RORγt-CBFβ interaction in Th17 cells but not in thymocytes.

物理化学性质&存储条件

分子量 495.86
分子式 C22H18ClF4N5O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-(4-(3-(2-chloro-6-fluorophenyl)-4-(pyrimidin-2-yl)isoxazol-5-yl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)-2-methylbutan-2-ol

参考文献

1. Patent WO2019048541. 2019-03-14.
2. Wu H, et al. J Clin Invest. 2026 Jan 2;136(1):e185942.

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