IMPDH2 inhibitor Comp-10

Chemical Structure : IMPDH2 inhibitor Comp-10

加入收藏

货号: PC-25669Not For Human Use, Lab Use Only.

IMPDH2 inhibitor Comp-10 is a specific, allosteric inhibitor of Inosine monophosphate dehydrogenase-2 (IMPDH2) with IC50 of 260 nM, disrupts R/R formation, and prevents tumor cell proliferation.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

IMPDH2 inhibitor Comp-10 is a specific, allosteric inhibitor of Inosine monophosphate dehydrogenase-2 (IMPDH2) with IC50 of 260 nM, disrupts R/R formation, and prevents tumor cell proliferation.
Comp-10 decreases IMPDH1/2 protein levels, blocks filament (rod/ring) formation, and inhibits the growth of ALK and BTK inhibitor-resistant lymphoma cells.
Comp-10 shows (1 uM) potent inhibition (>93%) of recombinant human IMPDH2 activity.
Comp-10 downregulates IMPDH1/2 expression and prevents filament (rod/ring) formation in ALCL and MCL models.
Comp-10 inhibits proliferation and colony formation in ALK-positive lymphoma cells.

物理化学性质&存储条件

分子量	441.28
分子式	C18H21BrN2O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-bromo-5,8-dihydroxy-7-(4-(2-(2-hydroxyethoxy)ethyl)piperazin-1-yl)naphthalene-1,4-dione

参考文献

1. Pattabiraman N, et al. Cancers (Basel). 2025 Oct 21;17(20):3389.