IMP-1710 (IMP1710)

Chemical Structure : IMP-1710

CAS No.: 2383117-96-0

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货号: PC-72219Not For Human Use, Lab Use Only.

IMP-1710 (IMP1710) is a potent, selective, covalent UCHL1 inhibitor with IC50 of 38 nM.

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生物&药学活性

IMP-1710 (IMP1710) is a potent, selective, covalent UCHL1 inhibitor with IC50 of 38 nM.
IMP-1710 demonstrated exquisite selectivity in a cross-screening against 20 DUBs.
IMP-1710 can profile activity of endogenous UCHL1 with excellent selectivity in cell types including endothelial cells (EA.hy926) and adenocarcinoma human alveolar basal epithelial cells (A549).
IMP-1710 demonstrated >50% fibroblast–myofibroblast transition (FMT) inhibition (IC50=740 nM) in idiopathic pulmonary fibrosis (IPF), as well as αSMA inhibition.
IMP-1710 is a powerful and selective probe to explore UCHL1 activity with potential application to substrate identification, mode of action studies, and cellular target profiling.

物理化学性质&存储条件

分子量	381.439
分子式	C23H19N5O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-2-(4-(5-ethynyl-1H-pyrrolo[2,3-b]pyridin-3-yl)indoline-1-carbonyl)pyrrolidine-1-carbonitrile

参考文献

1. Nattawadee Panyain, et al. J Am Chem Soc. 2020 Jul 15;142(28):12020-12026.

IMP-1710 (IMP1710)

生物&药学活性

物理化学性质&存储条件

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IMP-1710 (IMP1710)

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