IMB-9C

Chemical Structure : IMB-9C

加入收藏

货号: PC-25870Not For Human Use, Lab Use Only.

IMB-9C is a specific small molecule inhibitor of heptad repeat 1/heptad repeat 2 (HR1/HR2) interaction, inhibits SARS-CoV-2-S-mediated cell-cell fusion.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

IMB-9C is a specific small molecule inhibitor of heptad repeat 1/heptad repeat 2 (HR1/HR2) interaction, inhibits SARS-CoV-2-S-mediated cell-cell fusion.
IMB-9C exhibits a dose-dependent inhibitory effect on viral entry with EC50 of 32.15 uM.
IMB-9C demonstratesenhanced potency against Omicron variants compared with WT and previous variants.
IMB-9C inhibits virus-induced CPE for WT, Beta, Delta, Ba.1, Ba.2, Ba.4 and Ba.5, with IC50 values of 0.4 -3.1 uM, with low toxicity on mammalian cells such as HEK-293T, Huh-7 and Vero cells.
IMB-9C is able to block 6-HB formation between HR1 and HR2, binds with both HR1 and HR2 with SPR KD of 0.567 uM and 36.8 uM respectively.

物理化学性质&存储条件

分子量	444.45
分子式	C23H20N6O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-oxo-4-phenylpyrimidin-1(6H)-yl)-N-(3-nitrophenyl)acetamide

参考文献

1. Patent CN120037235 A 2025-05-27.

2. Zhang J, et al. Acta Pharm Sin B. 2025 Sep;15(9):4829-4843.

IMB-9C

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

IMB-9C

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.