IKAM-1 (Compound 39-100)

Chemical Structure : IKAM-1

CAS No.: 2345648-37-3

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货号: PC-38626Not For Human Use, Lab Use Only.

IKAM-1 (Compound 39-100) is an orally bioavailable, small-molecule IKKβ activation modulator (IKAM) that selectively targets MAP3K1, inhibits TNF-α-induced IKKβ-mediated NF-κB activation in A549 cells with IC50 of 4.7 uM.

规格	价格	库存
5 mg	￥2480	In stock
10 mg	￥3980	In stock
25 mg	￥5880	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

IKAM-1 (Compound 39-100) is an orally bioavailable, small-molecule IKKβ activation modulator (IKAM) that selectively targets MAP3K1, inhibits TNF-α-induced IKKβ-mediated NF-κB activation in A549 cells with IC50 of 4.7 uM.
IKAM-1 (Compound 39-100) selectively binds to MAP3K1 and MAP3K12, inhibits MAP3K1 with IC50 of 4.2 uM, does not inhibit IKKβ but selectively inhibits MAP3K1 with micromolar potency in PANC1 cell lysates.
IKAM-1 (Compound 39-100) inhibits MAP3K1-mediated IKKβ phosphorylation and reduced levels of p-IKKβ in with an IC50 value of 2.3 uM, inhibits the growth of PC lines with lowmicromolar potencies.
IKAM-1 (Compound 39-100) reduces activated IKKβ levels, inhibits tumor growth, and reduces metastasis in mice pancreatic tumor models.

物理化学性质&存储条件

分子量	441.26
分子式	C19H14BrFN6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(3-bromo-4-fluorophenyl)-3-(3-(1-methyl-1H-pyrazol-4-yl)quinoxalin-6-yl)urea

参考文献

1. Napoleon JV, et al. Proc Natl Acad Sci U S A. 2022 May 3;119(18):e2115071119.