IJ-5 |CAS:68776-47-6 Probechem Biochemicals

Chemical Structure : IJ-5

CAS No.: 68776-47-6

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IJ-5 (IJ5;IJ 5;1beta-Hydroxyalantolactone)

货号: PC-60355Not For Human Use, Lab Use Only.

A potent, covalent inhibitor of ubiquitin-conjugating enzyme UbcH5 with Kd of 5.189 uM, 3.578 uM, and 2.577 uM for UbcH5a, UbcH5b, and UbcH5c, respectively.

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1 mg	￥2480	In stock
5 mg	￥4580	In stock
10 mg	￥7880	In stock
25 mg		Get quote
100 mg		Get quote

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生物&药学活性

IJ-5 (1beta-Hydroxyalantolactone) is a potent, covalent inhibitor of ubiquitin-conjugating enzyme UbcH5 with Kd of 5.189 uM, 3.578 uM, and 2.577 uM for UbcH5a, UbcH5b, and UbcH5c, respectively.
IJ-5 shows weak affinity for Ubc13 (Kd=13.37 uM); inhibits TNFα-induced NF-kB pathway activation and inflammatory gene expression in 293T cells.
IJ-5 exhibites potent anti-inflammatory activity against TNF-α- and D-galactosamine-induced hepatitis and collagen-induced arthritis in preclinical models.

物理化学性质&存储条件

分子量	248.322
分子式	C15H20O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3aS,5R,8S,8aS,9aS)-8-hydroxy-5,8a-dimethyl-3-methylene-3a,5,6,7,8,8a,9,9a-octahydronaphtho[2,3-b]furan-2(3H)-one

参考文献

1. Liu L, et al. Chem Biol. 2014 Oct 23;21(10):1341-50.

2. Chen H, et al. J Med Chem. 2017 Jul 11. doi: 10.1021/acs.jmedchem.6b01829.

IJ-5 (IJ5;IJ 5;1beta-Hydroxyalantolactone)

生物&药学活性

物理化学性质&存储条件

参考文献

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IJ-5 (IJ5;IJ 5;1beta-Hydroxyalantolactone)

生物&药学活性

物理化学性质&存储条件

参考文献

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