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首页-小分子抑制剂&激动剂-GPCR-5-HT Receptor-IHCH-7113
IHCH-7113

Chemical Structure : IHCH-7113

CAS No.: 313368-85-3

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IHCH-7113 (IHCH7113)

货号: PC-28307Not For Human Use, Lab Use Only.

IHCH-7113 is a selective agonist of serotonin 2A receptor (5-HT2AR) with EC50 of 58.9 nM in Gq BRET assay and 44.7 nM in β-arrestin 2 BRET assays, activates both Gαq-mediated signaling pathways and β-arrestin 2 recruitment pathways and shows antidepressant activity.

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100 mg ￥580 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

IHCH-7113 is a selective agonist of serotonin 2A receptor (5-HT2AR) with EC50 of 58.9 nM in Gq BRET assay and 44.7 nM in β-arrestin 2 BRET assays, activates both Gαq-mediated signaling pathways and β-arrestin 2 recruitment pathways and shows antidepressant activity.

物理化学性质&存储条件

分子量 229.33
分子式 C14H19N3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(6bR,10aS)-3-Methyl-2,3,6b,7,8,9,10,10a-octahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline

参考文献

1. Dongmei Cao, et al. Science. 2022 Jan 28;375(6579):403-411.

2. Duan W, et al. Chemical reviews. 2024 Jan 10;124(1):124-163.

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