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首页-小分子抑制剂&激动剂-GPCR-Adenosine Receptor-IHCH-3185
IHCH-3185

Chemical Structure : IHCH-3185

CAS No.: 3124437-18-6

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IHCH-3185 (IHCH3185)

货号: PC-28312Not For Human Use, Lab Use Only.

IHCH-3185 is a potent, dual-targeting adenosine A2A receptor (A2AR) antagonist and HDAC inhibitor with Ki of 7.6 nM (A2AR) and IC50 of 102.9 nM (HDAC1) respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

IHCH-3185 is a potent, dual-targeting adenosine A2A receptor (A2AR) antagonist and HDAC inhibitor with Ki of 7.6 nM (A2AR) and IC50 of 102.9 nM (HDAC1) respectively.
IHCH-3185 demonstrates broad-spectrum antiproliferative activity in vitro.
IHCH-3185 (20 mg/kg, oral) significantly inhibited CT26 and MC38 tumor growth in mice with tumor growth inhibition rates of 68.5% and 71.1%, respectively.

物理化学性质&存储条件

分子量 455.48
分子式 C24H21N7O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-(2-((5-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-c]pyrimidin-7-yl)oxy)ethyl)-N-(2-aminophenyl)benzamide

参考文献

1. Wenzhong Yan, et al. J Med Chem. 2026 Mar 12;69(5):6038-6062.

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