IGS-2.7

Chemical Structure : IGS-2.7

CAS No.: 1579991-01-7

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货号: PC-25908Not For Human Use, Lab Use Only.

IGS-2.7 is a potent, selective and brain permeable CK1delta (CK-1δ, CK1δ) inhibitor with IC50 of 23 nM, >35-fold selective over CK1ε (IC50=840 nM).

规格	价格	库存
5 mg	￥1980	In stock
10 mg	￥2980	In stock
25 mg	￥4880	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

IGS-2.7 is a potent, selective and brain permeable CK1delta (CK-1δ, CK1δ) inhibitor with IC50 of 23 nM, >35-fold selective over CK1ε (IC50=840 nM).
IGS-2.7 decreases TDP-43 phosphorylation and nuclear localization using a cell-based model of human lymphoblast from FTD patients carrying a progranulin (GRN) mutation。
IGS-2.7 produces a significant preservation of motor neurons in the anterior horn at lumbar level, a decrease in both astroglial and microglial reactivity in this area, and in TDP-43 phosphorylation in spinal cord samples.
IGS-2.7 recoveredTDP-43 homeostasis (phosphorylation and localization) in a human-based cell model from ALS patients.

物理化学性质&存储条件

分子量	370.77
分子式	C16H10ClF3N2OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(3-chlorophenyl)-N-(6-(trifluoromethyl)benzo[d]thiazol-2-yl)acetamide

参考文献

1. Martínez-González L, et al. Sci Rep. 2020 Mar 10;10(1):4449.

2. Gomez-Almeria M, et al. Neuropharmacology. 2025 Dec 11:110804.

IGS-2.7

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IGS-2.7

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