IDB-003 | Translation inhibitor | Probechem Biochemicals

Chemical Structure : IDB-003

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IDB-003 (IDB003)

货号: PC-26086Not For Human Use, Lab Use Only.

IDB-003 is an orally active, unique context-dependent inhibitor of human translation that bind to the ribosome peptidyl transferase center (PTC) and inhibits elongation.

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生物&药学活性

IDB-003 is an orally active, unique context-dependent inhibitor of human translation that bind to the ribosome peptidyl transferase center (PTC) and inhibits elongation.
IDB-003 potently inhibited cell proliferation in MYC-dependent cancer cell lines, including prostate (22Rv1), colorectal (LS411N), HR+, HER2- breast (MCF7) and TNBC (HCC-1143) when compared to fibroblasts (MRC5), with EC50 values in the nanomolar range. Treatment of MCF7 cells with 1 µM IDB-003 led to rapid depletion of CCND1 evident by 1–2 h and reduction in MYC levels observable after 2 h of treatment.
IDB-003 stalled ribosomes within the coding sequences of MYC, CCND1 and CDK4, supporting a direct mechanism for their depletion.
IDB-003 inhibits tumor growth of MDA-MB-231 xenografts in vivo and depletes short-lived oncoproteins.

物理化学性质&存储条件

分子量	411.43
分子式	C22H22FN3O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2R,3S,4S)-4-hydroxy-2-(4-(oxazol-5-yl)benzyl)pyrrolidin-3-yl (3-fluorobenzyl)carbamate

参考文献

1. Diamond PD, et al. Nat Commun. 2026 Feb 24;17:1963.

IDB-003 (IDB003)

生物&药学活性

物理化学性质&存储条件

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IDB-003 (IDB003)

生物&药学活性

物理化学性质&存储条件

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