ICA00600232 | Nav1.1 potentiator | Probechem Biochemicals

Chemical Structure : ICA00600232

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ICA00600232 (ICA-00600232)

货号: PC-25532Not For Human Use, Lab Use Only.

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50 mg		Get quote
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250 mg		Get quote

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生物&药学活性

ICA00600232 is a potent, selective small molecule Nav1.1 sodium channel potentiator with EC50 of 24 nM, exhibits >1000-fold selectivity for human Nav1.1 over all other Nav1.x family members except Nav1.3 (EC50=98 nM).
ICA00600232 displays comparative EC50s for Nav1.1 potentiation for rodents (mouse and rat), dog, pig, and nonhuman primates (marmoset and cynomolgus monkey), with 2- to 5-fold different from the 24 nM (human Nav1.1).
ICA00600232 (1 uM) produces an 11 mV depolarizing shift in voltage-dependence of activation of human Nav1.1 and a larger 23 mV depolarizing shift in voltage-dependence of steady-state inactivation.
ICA00600232 interacts with homologous domain 4 of Nav1.1.
ICA00600232 (10 nM-1 uM) increases excitability of cortical interneurons from scn1a+/− and wild-type mice.

物理化学性质&存储条件

分子量	451.48
分子式	C24H23F2N5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-(2,5-difluorophenyl)-6-(2-oxa-6-azaspiro[3.3]heptan-6-yl)pyrimidin-5-yl)-6-isopropyl nicotinamide

参考文献

1. Gallucci A, et al. Mol Pharmacol. 2025 Aug 21;107(10):100072.

ICA00600232 (ICA-00600232)

生物&药学活性

物理化学性质&存储条件

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ICA00600232 (ICA-00600232)

生物&药学活性

物理化学性质&存储条件

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