ICA-1 | PKC-iota inhibitor | Probechem Biochemicals

Chemical Structure : ICA-1

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ICA-1 (PKC-iota inhibitor)

货号: PC-35336Not For Human Use, Lab Use Only.

ICA-1 is a potent, specific inhibitor of Protein Kinase C-iota (PKC-ι) with IC50 of 0.1 uM, does not inhibit PKC-ζ, the closely related atypical PKC family member.

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100 mg		Get quote
250 mg		Get quote

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生物&药学活性

ICA-1 is a potent, specific inhibitor of Protein Kinase C-iota (PKC-ι) with IC50 of 0.1 uM, does not inhibit PKC-ζ, the closely related atypical PKC family member.
ICA-1 potently inhibits the phosphorylation of Cdk7 by PKC-ι, inhibits PKC-ι/Cdk7/cdk2 cell signaling pathway and exhibits antiproliferative effects in neuroblastoma cells, also induces apoptosis.
ICA-1 significantly reduces migration and melanoma cell invasion, downregulates TNF-α induced NF-κB translocation to the nucleus there by inducing apoptosis.

物理化学性质&存储条件

分子量	336.241
分子式	C10H17N4O7P
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-Amino-1-[(1R,2S,3R,4R)-2,3-dihydroxy-4-[(phosphonooxy)methyl]cyclopentyl]-1H-imidazole-4-carboxamide

参考文献

1. Pillai P, et al. Int J Biochem Cell Biol. 2011 May;43(5):784-94.

2. McCray AN, et al. Neurochem Res. 2014 Sep;39(9):1691-701.

3. Ratnayake WS, et al. Cell Adh Migr. 2018 May 21:1-17.