IBX-204 | ISR modulator, GCN2 inhibitor | Probechem Biochemicals

Chemical Structure : IBX-204

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IBX-204 (IBX204)

货号: PC-24999Not For Human Use, Lab Use Only.

IBX-204 is a selective integrated stress response (ISR) modulator targeting stress sensor kinase GCN2, selectively eliminates ISR-high cells across diverse stressors.

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生物&药学活性

IBX-204 is a selective integrated stress response (ISR) modulator targeting stress sensor kinase GCN2, selectively eliminates ISR-high cells across diverse stressors.
IBX-204 inhibits opto-PKR cells with IC50 of 0.5 uM for 24 h in light, is not acutely cytotoxic to opto-PKR cells in dark uo to 50 uM.
IBX-204 increase ATF4 and CHOP expression, resulting in ATF4- and CHOP-mediated sensitivity to thapsigargin stress and ATP depletion as a hallmark of high ATF4 expression, upregulates ATF4 and DDIT3 (CHOP) in an ISR-pathway-specific manner.
IBX-204 selectively binds to GCN2 with Kd value of 3.2 uM.
IBX-204 selectively decreases GCN2 kinase activity with IC50 of 50 uM.
IBX-204 shows selective and broad-spectrum antiviral activity, decreases HSV-1 titers in vivo.

物理化学性质&存储条件

分子量	489.53
分子式	C26H27N5O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	ethyl 4-(4-(3-(2,3-dimethoxyphenyl)-1,2,4-oxadiazol-5-yl)quinolin-2-yl)piperazine-1-carboxylate

参考文献

1. Wong F, et al. Cell. 2025 Jul 3:S0092-8674(25)00690-7.

IBX-204 (IBX204)

生物&药学活性

物理化学性质&存储条件

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IBX-204 (IBX204)

生物&药学活性

物理化学性质&存储条件

参考文献

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