欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-IRE1-IAPD1
IAPD1

Chemical Structure : IAPD1

CAS No.:

加入收藏

IAPD1

货号: PC-25598Not For Human Use, Lab Use Only.

IAPD1 is the ester prodrug of IA107 with improved cellular permeability, IA107 is a potent and selective inositol-requiring enzyme 1 alpha (IRE1α) inhibitor, IAPD1 potently inhibits ER stress-induced XBP1 splicing in A549 cells with IC50 of 180 nM.

规格 价格 库存 数量
50 mg Get quote
100 mg Get quote
250 mg Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

IAPD1 is the ester prodrug of IA107 with improved cellular permeability, IA107 is a potent and selective inositol-requiring enzyme 1 alpha (IRE1α) inhibitor, IAPD1 potently inhibits ER stress-induced XBP1 splicing in A549 cells with IC50 of 180 nM.
IAPD1 inhibits the XBP1 mRNA splicing with IC50 of 220 nM and 160 nM in HCT 116 cells and HT-29 cells, respectively.
IAPD1 doe not affect the IRE1α protein level.
IAPD1 not show any detectable activity against IRE1α in the FRET assay and LanthaScreen kinase binding assay.

物理化学性质&存储条件

分子量 414.30
分子式 C21H20BrNO3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

ethyl 3-(1-benzoyl-5-bromo-2-methyl-1H-indol-3-yl)propanoate

参考文献

1. Liu Y, et al. Nat Commun. 2025 Sep 26;16(1):8531.

备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

联系我们 sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

询单

  • *产品名称:
  • *姓名:
  • *邮箱:
  • *公司名称:
  • *询单数量:
  • *国籍:
  • 询单信息: