IAP-08 | SMYD3 PROTAC | Probechem Biochemicals

Chemical Structure : IAP-08

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IAP-08 (IAP08)

货号: PC-28478Not For Human Use, Lab Use Only.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

IAP-08 is a potent, selective SMYD3 proteolysis targeting chimera (PROTAC) degrader with DC50 of 177 nM and Dmax of 90% in HiBiT-tagged SMYD3 expressing HN13 cells, effectively induces the formation of ternary complexes with SMYD3 and the XIAP E3 ligase.
IAP-08 significantly decreases the proliferative and invasive capacity of HPV-negative HNSCC cells.
IAP-08 (12.5 mg/kg, i.v.) shows a favorable pharmacokinetic profile in vivo.
IAP-08 regulates the transcription of cell cycle-, EMT- and immune-related genes in HPV-negative HNSCC cells.

物理化学性质&存储条件

分子量	1276.01
分子式	C70H83ClN10O9S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-chloro-N-((1R,3r,5S)-8-(((1-(3-(4-((4-(((3S,5S)-1-((S)-2-cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)-5-(((R)-1,2,3,4-tetrahydronaphthalen-1-yl)carbamoyl)pyrrolidin-3-yl)carbamoyl)phenyl)buta-1,3-diyn-1-yl)benzamido)propyl)piperidin-4-yl)methyl)sulfonyl)-8-azabicyclo[3.2.1]octan-3-yl)-2-oxoindoline-5-carboxamide

参考文献

1. Akhtar J, et al. bioRxiv [Preprint]. 2026 Sep 29:2026.09.28.754983.

IAP-08 (IAP08)

生物&药学活性

物理化学性质&存储条件

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IAP-08 (IAP08)

生物&药学活性

物理化学性质&存储条件

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