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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-YAP-TEAD-IAG933
IAG933

Chemical Structure : IAG933

CAS No.: 2714434-21-4

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IAG933 (IAG-933, IAG 933)

货号: PC-20801Not For Human Use, Lab Use Only.

IAG933 (IAG-933) is a potent, selective and orally efficacious YAP1/WWTR1(TAZ)-panTEAD protein-protein interaction inhibitor (YAP/TAZ-TEADs PPI), inhibits TEAD-driven transcriptional activity and displays anti-cancer effects.

规格 价格 库存 数量
2 mg ￥1580 In stock
5 mg ￥2780 In stock
10 mg ￥4580 In stock
25 mg ￥7580 In stock
50 mg Get quote
100 mg Get quote
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纯度 & COA & 质检文件 纯度: 98.5% (HPLC) Select Batch:

生物&药学活性

IAG933 (IAG-933) is a potent, selective and orally efficacious YAP1/WWTR1(TAZ)-pan TEAD protein-protein interaction inhibitor (YAP/TAZ-TEADs PPI), inhibits TEAD-driven transcriptional activity and displays anti-cancer effects.
IAG933 specifically abrogates the interaction between YAP/TAZ coactivators and all four TEAD isoforms, thus selectively inhibiting TEAD-driven transcriptional activity and inducing anti-cancer effects.
IAG933 exhibits robust anti-tumor efficacy in cancer models bearing NF2 loss of function or expressing TAZ-fusions.
IAG933 also shows combination benefits with several MAPK/KRAS inhibitors, both in vitro and in vivo, in non-Hippo altered models including lung, pancreatic and colorectal cancer.

物理化学性质&存储条件

分子量 529.97
分子式 C27H26ClF2N3O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-((S)-5-chloro-6-fluoro-2-phenyl-2-((S)-pyrrolidin-2-yl)-2,3-dihydrobenzofuran-4-yl)-5-fluoro-6-(2-hydroxyethoxy)-N-methylnicotinamide

参考文献

1. Tobias Schmelzle, et al. Cancer Res (2023) 83 (8_Supplement): LB319.
2. Emilie A Chapeau, et al. Nat Cancer. 2024 Jul;5(7):1102-1120.

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