IACS-56676 | NRAS G12D inhibitor | Probechem Biochemicals

Chemical Structure : IACS-56676

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IACS-56676 (IACS56676)

货号: PC-26265Not For Human Use, Lab Use Only.

IACS-56676 is a selective and potent NRAS G12D inhibitor with target engagement IC50 of 31 nM in AlphaLISA p-ERK1/2 assays, and IC50 of 73 nM in THP1 cell viability assay, displays >100-fold selectivity for NRAS G12D over KRAS wild type.

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生物&药学活性

IACS-56676 is a selective and potent NRAS G12D inhibitor with target engagement IC50 of 31 nM in AlphaLISA p-ERK1/2 assays, and IC50 of 73 nM in THP1 cell viability assay, displays >100-fold selectivity for NRAS G12D over KRAS wild type.

物理化学性质&存储条件

分子量	562.01
分子式	C28H28ClF4N5O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-((6-(5-amino-3-chloro-2-(trifluoromethyl)phenyl)-3-((1R,5S,6s)-3-azabicyclo[3.1.0]hexan-6-yl)-1,4-dicyclopropyl-7-fluoro-1H-pyrrolo[3,2-c]pyridin-2-yl)methyl)acetamide

参考文献

1. Cox JB, et al. ACS Med Chem Lett. 2026 Jan 22;17(2):425-432.

IACS-56676 (IACS56676)

生物&药学活性

物理化学性质&存储条件

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IACS-56676 (IACS56676)

生物&药学活性

物理化学性质&存储条件

参考文献

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