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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-DNA Repair Protein -IACS-4759
IACS-4759

Chemical Structure : IACS-4759

CAS No.: 1884209-99-7

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IACS-4759 (IACS4759)

货号: PC-62705Not For Human Use, Lab Use Only.

IACS-4759 is a potent, selective aminopyrimidine MTH1 (MutT homolog 1) inhibitor with IC50 of 0.6 nM.

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5 mg ￥880 In stock
10 mg ￥1280 In stock
25 mg ￥1980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

IACS-4759 is a potent, selective aminopyrimidine MTH1 (MutT homolog 1) inhibitor with IC50 of 0.6 nM.
IACS-4759 shows no off-target kinase activity in a panel of 97 kinases.
IACS-4759 exhibits excellent cell permeability and good metabolic stability in microsomes.
IACS-4759 is an excellent tool for interrogation of the utility of MTH1 inhibition in the context of oncology.

物理化学性质&存储条件

分子量 211.265
分子式 C10H17N3O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-((2-amino-5-methylpyrimidin-4-yl)oxy)-2,2-dimethylpropan-1-ol

参考文献

1. Petrocchi A, et al. Bioorg Med Chem Lett. 2016 Mar 15;26(6):1503-7.

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