I942 | EPAC1 agonist | Probechem Biochemicals

Chemical Structure : I942

CAS No.: 868145-09-9

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I942 (I-942)

货号: PC-25214Not For Human Use, Lab Use Only.

I942 is a specific, small molecule partial agonist of cyclic AMP sensor EPAC1 with AC50 of 50 uM, shows no effect on EPAC2.

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生物&药学活性

I942 is a specific, small molecule partial agonist of cyclic AMP sensor EPAC1 with AC50 of 50 uM, shows no effect on EPAC2.
I942 inhibits cAMP-induced activation of EPAC1 in a concentration dependent manner.
I942 and cAMP compete for binding to the CNB domain with similar affinities.
I942 has partial agonist properties towards EPAC1, leading to activation of EPAC1, in the absence of cAMP, and inhibition of GEF activity in the presence of cAMP.
I942 shows potential to suppress pro-inflammatory cytokine signalling with a reduced risk of side effects associated with general cAMP-elevating agents that activate multiple response pathways.

物理化学性质&存储条件

分子量	369.44
分子式	C20H19NO4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-((2,4-Dimethylphenyl)sulfonyl)-2-(naphthalen-2-yloxy)acetamide

参考文献

1. Parnell E, et al. Sci Rep. 2017 Mar 22;7(1):294.

2. Barker G, et al. J Cardiovasc Dev Dis. 2017 Dec 5;4(4):22.

I942 (I-942)

生物&药学活性

物理化学性质&存储条件

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I942 (I-942)

生物&药学活性

物理化学性质&存储条件

参考文献

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