I3IN-002

Chemical Structure : I3IN-002

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货号: PC-25825Not For Human Use, Lab Use Only.

I3IN-002 is a small molecule inhibitor of RNA-binding protein IGF2BP3, inhibits IGF2BP3-RNA interactions and shows leukemic cell growth-inhibitory activity with IC50 of ~2 µM in wild-type SEM-cells.

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生物&药学活性

I3IN-002 is a small molecule inhibitor of RNA-binding protein IGF2BP3, inhibits IGF2BP3-RNA interactions and shows leukemic cell growth-inhibitory activity with IC50 of ~2 µM in wild-type SEM-cells.
I3IN-00 inhibits cell proliferation and cell cycle progression and promotes apoptosis in SEM, RS4;11 Lin-MLL-Af4 and MV4;11 cells.
I3IN-00 reduces leukemia-initiating cells and leukemia engraftment in vivo.
I3IN-002 inhibits IGF2BP3-dependent gene expression changes, inhibits the molecular function of IGF2BP3 in post-transcriptional gene regulation.

物理化学性质&存储条件

分子量	431.44
分子式	C20H16F3N5OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((8-ethyl-5H-[1,2,4]triazino[5,6-b]indol-3-yl)thio)-N-(2-(trifluoromethyl)phenyl)acetamide

参考文献

1. Jaiswal AK, et al. Haematologica. 2025 Nov 27. doi: 10.3324/haematol.2025.288221.

2. Patent WO2025024377 A1.

I3IN-002

生物&药学活性

物理化学性质&存储条件

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I3IN-002

生物&药学活性

物理化学性质&存储条件

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