I-0436650 | SHP2 inhibitor | Probechem Biochemicals

Chemical Structure : I-0436650

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I-0436650 (I0436650)

货号: PC-27630Not For Human Use, Lab Use Only.

I-0436650 is a potent, selective and allosteric inhibitor of human wild-type (wt) SHP2 with nanomolar potency, strongly inhibits ERK phosphorylation, exhibits antiproliferative activity in EGFR- and RAS-dependent cell lines.

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生物&药学活性

I-0436650 is a potent, selective and allosteric inhibitor of human wild-type (wt) SHP2 with nanomolar potency, strongly inhibits ERK phosphorylation, exhibits antiproliferative activity in EGFR- and RAS-dependent cell lines.

物理化学性质&存储条件

分子量	479.99
分子式	C22H22ClN9S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-1-(5-((3-chloro-2-(1H-pyrazol-1-yl)pyridin-4-yl)thio)pyrazin-2-yl)-4'H,6'H-spiro[piperidine-4,5'-pyrrolo[1,2-b]pyrazol]-4'-amine

参考文献

1. Ciammaichella A, et al. J Med Chem. 2026 Aug 13;69(15):18898-18914.

I-0436650 (I0436650)

生物&药学活性

物理化学性质&存储条件

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I-0436650 (I0436650)

生物&药学活性

物理化学性质&存储条件

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