Huib32 | USP32 inhibitor | Probechem Biochemicals

Chemical Structure : Huib32

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Huib32 (USP32 inhibitor)

货号: PC-26593Not For Human Use, Lab Use Only.

Huib32 is a potent, selective small-molecule inhibitor of USP32 with IC50 of 21.2 nM, high selectivity over other closely related deubiquitinating enzymes (DUBs).

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5 mg	￥4580	In stock
10 mg	￥7280	In stock
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生物&药学活性

Huib32 is a potent, selective small-molecule inhibitor of USP32 with IC50 of 21.2 nM in an activity assay using Ub-RhoMP.
Huib32 shows high selectivity over other closely related deubiquitinating enzymes (DUBs), such as USP8/10/16, UCHL1 and OTUB2.
Huib32 reversibly inhibits USP32 by covalently binding to the active site Cys743, which enhances substrate ubiquitination, alters endosomal morphology, and mimics USP32 depletion.

物理化学性质&存储条件

分子量	381.45
分子式	C16H23N5O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-N-(1-cyanopyrrolidin-3-yl)-1-((3,5-dimethylisoxazol-4-yl)sulfonyl)piperidine-4-carboxamide

参考文献

1. Stephan Scherpe, et al. bioRxiv. doi: https://doi.org/10.1101/2025.04.19.649632

Huib32 (USP32 inhibitor)

生物&药学活性

物理化学性质&存储条件

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Huib32 (USP32 inhibitor)

生物&药学活性

物理化学性质&存储条件

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