HuR inhibitor 7a

Chemical Structure : HuR inhibitor 7a

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货号: PC-27587Not For Human Use, Lab Use Only.

HuR inhibitor 7a is a potent HuR inhibitor with Ki of 98 nM, and IC50 of 1.33 uM against MDA-MB-231 cells.

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生物&药学活性

HuR inhibitor 7a is a potent HuR inhibitor with Ki of 98 nM, and IC50 of 1.33 uM against MDA-MB-231 cells.
HuR inhibitor 7a induces cancer cell apoptosis by reducing the expression levels of prosurvival proteins encoded by HuR target mRNAs, including XIAP, Bcl-2, and Survivin, without altering HuR protein abundance.

物理化学性质&存储条件

分子量	693.80
分子式	C35H31N7O5S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S,E)-4-(3-((7H-purin-6-yl)thio)propoxy)-N-(1-((2-(3-(hydroxyamino)-3-oxoprop-1-en-1-yl)benzo[b]thiophen-5-yl)amino)-1-oxo-3-phenylpropan-2-yl)benzamide

参考文献

1. Li Z, et al. Biochem Biophys Res Commun. 2026 Jul 31;832:154382.

HuR inhibitor 7a

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HuR inhibitor 7a

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