HhAntag | SHH signaling inhibitor, Smo inhibitor | Probechem Biochemicals

Chemical Structure : HhAntag

CAS No.: 496794-70-8

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HhAntag (Hh-Antag691)

货号: PC-25922Not For Human Use, Lab Use Only.

HhAntag (HhAntag-691) is a potent, specific, and orally active small molecule Smoothened (Smo) antagonist, inhibits Sonic Hedgehog (Shh) pathway.

规格	价格	库存
5 mg	￥1380	In stock
10 mg	￥2180	In stock
25 mg	￥3780	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

HhAntag (HhAntag-691) is a potent, specific, and orally active small molecule Smoothened (Smo) antagonist, inhibits Sonic Hedgehog (Shh) pathway.
HhAntag inhibits Gli1 expression in a dose-dependent manner in tumor tissue in vivo.
HhAntag at 20 or 100 mg/kg of body weight, by oral gavage, for 4 days, inhibited tumor cell proliferation and increased apoptosis.
HhAntag inhibits not only hedgehog signaling, but also modulates canonical and non-canonical BMP signaling and blocks basal and rhBMP2-stimulated chondrogenesis

物理化学性质&存储条件

分子量	450.92
分子式	C24H23ClN4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-Chloro-3-(6-(dimethylamino)-1H-benzo[d]imidazol-2-yl)phenyl)-3,5-dimethoxybenzamide

参考文献

1. Romer JT, et al. Cancer Cell. 2004 Sep;6(3):229-40.

2. Gabay L, et al. Neuron. 2003 Oct 30;40(3):485-99.

3. Mundy C, et al. J Cell Physiol. 2016 May;231(5):1033-44.

HhAntag (Hh-Antag691)

生物&药学活性

物理化学性质&存储条件

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HhAntag (Hh-Antag691)

生物&药学活性

物理化学性质&存储条件

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