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首页-小分子抑制剂&激动剂-PI3K/Akt/mTOR Pathway-AMPK-Hernandezine
Hernandezine

Chemical Structure : Hernandezine

CAS No.: 6681-13-6

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Hernandezine (Hernandesine)

货号: PC-27916Not For Human Use, Lab Use Only.

Hernandezine is an alkaloid isolated from roots of Thalictrum podocarpum., is an AMPK activator and induces autophagy and cell death, activates AMPK-mTOR signalling pathways.

规格 价格 库存 数量
5 mg ￥2180 In stock
10 mg ￥3580 In stock
25 mg ￥5580 In stock
50 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Hernandezine is an alkaloid isolated from roots of Thalictrum podocarpum., is an AMPK activator and induces autophagy and cell death, activates AMPK-mTOR signalling pathways.
Hernandezine inhibits calcium-depletion stimulated calcium entry in human and bovine endothelial cells
Hernandezine is also a potent inhibitor of protein kinase C signaling.
Hernandezine blocks the influx of calcium via non selective cation channels in HL-60 cells.
Hernandezine induces autophagic GFP-LC3 puncta in various types of cancer cells.
Hernandezine induces autophagic cell death in apoptosis-resistant cancer cells.

物理化学性质&存储条件

分子量 652.79
分子式 C39H44N2O7
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(11S,31S)-16,35,36,37,54-Pentamethoxy-12,32-dimethyl-11,12,13,14,31,32,33,34-octahydro-2,6-dioxa-1(7,1),3(8,1)-diisoquinolina-5(1,3),7(1,4)-dibenzenacyclooctaphane

参考文献

1. Law BY, et al. Oncotarget. 2016 Feb 16;7(7):8090-104.

2. Low AM, et al. Life Sci. 1996;58(25):2327-35.

3. Ho LJ, et al. Eur J Pharmacol. 1999 Feb 19;367(2-3):389-98.

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