Helios degrader ALV1 | Helios degrader | Probechem Biochemicals

Chemical Structure : Helios degrader ALV1

CAS No.: 2438124-79-7

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Helios degrader ALV1 (ALV-03-112-01)

货号: PC-38302Not For Human Use, Lab Use Only.

Helios degrader ALV1 (ALV-03-112-01) is a small molecule degrader of the zinc-finger transcription factor Helios with IC50 of 0.55 uM in CRBN-binding TR-FRET assay, exhibits similar degradation activity towards IKZF1/2/3.

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2 mg	￥1780	In stock
5 mg	￥2780	In stock
10 mg	￥4580	In stock
25 mg		Get quote

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生物&药学活性

Helios degrader ALV1 (ALV-03-112-01) is a small molecule degrader of the zinc-finger transcription factor Helios with IC50 of 0.55 uM in CRBN-binding TR-FRET assay, exhibits similar degradation activity towards IKZF1/2/3.
ALV1 recruits the E3 ubiquitin ligase substrate receptor cereblon to Helios.
ALV1 bound CRBN in vitro with greater potency than lenalidomide but less than CC-885.
ALV1 also induced CRBN-Helios dimerization in the TR-FRET assay, with greater activity than either CC-885. ALV1 degraded both Ikaros and Helios.

物理化学性质&存储条件

分子量	494.932
分子式	C25H23ClN4O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3-chloro-4-methylphenyl)-3-(3-((1-(2,6-dioxopiperidin-3-yl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl)amino)phenyl)propanamide

参考文献

1. Eric S Wang, et al. Nat Chem Biol. 2021 Jun;17(6):711-717.

Helios degrader ALV1 (ALV-03-112-01)

生物&药学活性

物理化学性质&存储条件

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Helios degrader ALV1 (ALV-03-112-01)

生物&药学活性

物理化学性质&存储条件

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