Heclin | HECT ligase inhibitor | Probechem Biochemicals

Chemical Structure : Heclin

CAS No.: 890605-54-6

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Heclin (HECT ligase inhibitor)

货号: PC-70324Not For Human Use, Lab Use Only.

Heclin is a small molecule inhibitor of HECT-type ubiquitin ligase with IC50 of 6.8/6.3/6.9 uM for Smurf2/Nedd4/WWP1, respectively.

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5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥1980	In stock
50 mg	￥2980	In stock
100 mg		Get quote

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生物&药学活性

Heclin is a small molecule inhibitor of HECT-type ubiquitin ligase with IC50 of 6.8/6.3/6.9 uM for Smurf2/Nedd4/WWP1, respectively.
Heclin does not block E2 binding but causes a conformational change that results in oxidation of the active site Cys.
Heclin is active against a range of HECT ligases but does not perturb the ubiquitin system more generally.

物理化学性质&存储条件

分子量	283.32
分子式	C17H17NO3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-Acetylphenyl)-3-(5-ethyl-2-furanyl)-2-propenamide

参考文献

1. Mund T, et al. Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):16736-41.

Heclin (HECT ligase inhibitor)

生物&药学活性

物理化学性质&存储条件

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Heclin (HECT ligase inhibitor)

生物&药学活性

物理化学性质&存储条件

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