HZX-02-059 | PIKfyve inhibitor | Probechem Biochemicals

Chemical Structure : HZX-02-059

CAS No.: 2240205-30-3

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HZX-02-059 (Methuosis inducer 1)

货号: PC-47003Not For Human Use, Lab Use Only.

HZX-02-059 is a PIKfyve and tubulin dual-target inhibitor with high affinity for PIKfyve (Kd=10.4 nM), HZX-02-059 is a potent methuosis inducer, shows both in vitro and in vivo anti-tumor activity against TNBC.

规格	价格	库存
5 mg	￥1980	In stock
10 mg	￥2980	In stock
25 mg	￥4980	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

HZX-02-059 (Methuosis inducer 1) is a PIKfyve and tubulin dual-target inhibitor with high affinity for PIKfyve (Kd=10.4 nM), HZX-02-059 is a potent methuosis inducer, shows both in vitro and in vivo anti-tumor activity against TNBC.
HZX-02-059 exerts anti-proliferative action of DHL cells in a dose- and time-dependent manner, including Will-2, LR, and TMD8 cells (IC50=150-350 nM, 48 h).
HZX-02-059 induces a caspase-independent cell death in DHL cells. HZX-02-059 triggers non-apoptotic cell death of methuosis as a result of PIKfyve/TFEB inhibition.
HZX-02-059-induced cell cycle arrest is mechanistically associated with the inhibition of tubulin and mTOR/Myc axis.
HZX-02-059 (20 mg/kg, i.p.) suppresses growth of xenograft derived from DHL cells with a low systemic toxicity profile.

物理化学性质&存储条件

分子量	487.486
分子式	C27H20F3N5O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-methyl-3-((6-(pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl)amino)phenyl)-3-(trifluoromethyl)benzamide

参考文献

1. Liying Feng, et al. Cell Death Discov. 2022 Jan 28;8(1):39.

HZX-02-059 (Methuosis inducer 1)

生物&药学活性

物理化学性质&存储条件

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HZX-02-059 (Methuosis inducer 1)

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物理化学性质&存储条件

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