HYPE inhibitor I2.10 | HYPE inhibitor | Probechem Biochemicals

Chemical Structure : HYPE inhibitor I2.10

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HYPE inhibitor I2.10 (AMPylase inhibitor I2.10)

货号: PC-22137Not For Human Use, Lab Use Only.

HYPE inhibitor I2.10 is a small molecule HYPE (Huntingtin Yeast Interacting Partner E, FICD) enzyme inhibitor with IC50 of 12.1 uM, inhibits HYPE-mediated AMPylation of BiP in vtro.

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生物&药学活性

HYPE inhibitor I2.10 is a small molecule HYPE (Huntingtin Yeast Interacting Partner E, FICD) enzyme inhibitor with IC50 of 12.1 uM, inhibits HYPE-mediated AMPylation of BiP in vtro.
I2.10 enacts a reliable inhibitory effect of AMPylation on HYPE's primary substrate, the ER chaperone BiP.
I2.10 is especially suited for development as a HYPE-specific drug for the treatment of clinical conditions of neurodegeneration and diabetes.
HYPE resides in the ER (endoplasmic reticulum) where it AMPylates the heat shock chaperone BiP (Binding Immunoglobulin Protein).

物理化学性质&存储条件

分子量	279.26
分子式	C14H9N5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(6-(1H-imidazol-1-yl)pyridin-3-yl)-5-(furan-3-yl)-1,3,4-oxadiazole

参考文献

1. Ali Camara, et al. Cell Stress Chaperones. 2024 Apr 8:S1355-8145(24)00063-4.

HYPE inhibitor I2.10 (AMPylase inhibitor I2.10)

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HYPE inhibitor I2.10 (AMPylase inhibitor I2.10)

生物&药学活性

物理化学性质&存储条件

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