HSP70-IN-27c

Chemical Structure : HSP70-IN-27c

CAS No.: 1268273-90-0

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货号: PC-43120Not For Human Use, Lab Use Only.

HSP70-IN-27c is a potent, irreversible inhibitor of Hsp70 without Hsp 90 binding activity, inhibits growth of Kasumi-1 AML cells with IC50 of 2.3 uM, and inhibits Caspase-3,7 activation in MOLM13 AML cells with IC50 of 1.9 uM.

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5 mg	￥2380	In stock
10 mg	￥3580	In stock
25 mg	￥5480	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

HSP70-IN-27c is a potent, irreversible inhibitor of Hsp70 without Hsp 90 binding activity, inhibits growth of Kasumi-1 AML cells with IC50 of 2.3 uM, and inhibits Caspase-3,7 activation in MOLM13 AML cells with IC50 of 1.9 uM.
HSP70-IN-27c inhibits HER2 and Raf-1 steady-state levels, PARP cleavage in SKBr3 breast cancer cells with IC50 of about 1.5 uM.
HSP70-IN-27c induces apoptosis in MDA-MB-468 cells.

物理化学性质&存储条件

分子量	464.5831
分子式	C24H28N6O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Acetamide, 2-amino-N-[3-[[2-(4-methyl-1-piperazinyl)-4-(phenylmethoxy)-5-pyrimidinyl]thio]phenyl]-

参考文献

1. Taldone T, et al. J Med Chem. 2014 Feb 27;57(4):1208-24.

HSP70-IN-27c

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