HSD17B13 inhibitor 32

Chemical Structure : HSD17B13 inhibitor 32

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货号: PC-24627Not For Human Use, Lab Use Only.

HSD17B13 inhibitor 32 is a highly potent, selective and liver-targeting HSD17B13 inhibitor with IC50 of 2.5 nM.

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生物&药学活性

HSD17B13 inhibitor 32 is a highly potent, selective and liver-targeting HSD17B13 inhibitor with IC50 of 2.5 nM.
HSD17B13 inhibitor 32 exhibits binding affinity (hKd = 19.3 nM) and inhibitory activity against murine HSD17B13 (IC50=55.1 nM).
HSD17B13 inhibitor 32 exhibits high selectivity (>100-fold) over other key MASH-related targets, including fatty-acid-binding proteins 1/4 (FABP1/4), free fatty acid receptor 1 (FFAR1), and 17 nuclear hormone receptors.
HSD17B13 inhibitor 32 maintains potent inhibition of HSD17B13 (IC50 = 7.6 nM) in enzymatic assay using leukotriene B4 (LTB4) as a cosubstrate.
HSD17B13 inhibitor 32 exhibits robust anti-MASH effects by regulating lipid metabolism, inflammation, fibrosis, and oxidative stress in diet-induced obesity (DIO) and MASH mouse models.

物理化学性质&存储条件

分子量	454.89
分子式	C21H18ClF3N2O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-Chlorobenzyl)-N-isopropyl-4-methyl-2-(2,4,5-trifluoro-3-hydroxyphenyl)thiazole-5-carboxamide

参考文献

1. Lianru Chen, et al. J Med Chem. 2025 May 19. doi: 10.1021/acs.jmedchem.5c00119.